Enalapril Reaction


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Our question this week was:

Our 13 year old cocker/terrier took her first dose of enalapril last night (10mg for her 43 lbs). She also took lasix for her cough and fluid build up. She was diagnosed with basically heart failure...(Her heart is round-shaped in pictures etc) This morning she changed completely. She did not urinate, eat or act her normal chipper self. She has vomited several times and is not herself at all. If it is a reaction (side-effect) to the drugs, how long will it take to get out of her system?


Brent McClun


Thanks for your email. Goodness, your situation sounds very unfortunate. Congestive Heart Failure (CHF) is common in dogs. Without actually seeing and examining your dog, to be honest, I'm not sure what is going on. The Lasix is a diuretic and generally causes increased urinations. The enalapril is in a class of drugs called "ACE inhibitors". Both drugs are commonly used to treat dogs with CHF.

I'd worry about a couple of things. Is the CHF getting worse or is there a secondary problem going on. It is possible that your dog is dehydrated or hypotensive (having a low blood pressure) making her weak. It is also possible that a secondary problem may be going on such as kidney failure.

I'd recommend taking her to your vet for revaluation immediately. If it is after hours, I'd go to your local emergency clinic.

An article that might be useful to you is: Congestive Heart Failure in Dogs.

Best of luck!

Dr. Debra

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debra-primovic Dr. Debra Primovic

Debra A. Primovic, BSN, DVM, Editor-in-Chief, is a graduate of the Ohio State University School of Nursing and the OSU College of Veterinary Medicine. Following her veterinary medical training, Dr. Primovic practiced in general small animal practices as well as veterinary emergency practices. She was staff veterinarian at the Animal Emergency Clinic of St. Louis, Missouri, one of the busiest emergency/critical care practices in the United States as well as MedVet Columbus, winner of the AAHA Hospital of the year in 2014. She also spends time in general practice at the Granville Veterinary Clinic. Dr. Primovic divides her time among veterinary emergency and general practice, editing, writing, and updating articles for PetPlace.com, and editing and indexing for veterinary publications. She loves both dogs and cats but has had extraordinary cats in her life, all of which have died over the past couple years. Special cats in her life were Kali, Sammy, Pepper and Beanie.