Chronic Active Hepatitis (CAH)

Section: Overview

Chronic active hepatitis (CAH) is a chronic and progressive inflammation of the liver of dogs that leads eventually to the replacement of normal liver tissue with scar tissue. The disease is also called chronic canine inflammatory hepatic disease. In most cases, the cause of this disorder is never discovered. Potential causes include canine hepatitis virus (adenovirus I), leptospirosis, copper storage disease, drug toxicity, and genetic factors. Reactions on the part of the immune system to the liver inflammation may contribute to the progressive worsening of the disease.

All breeds of dogs can be affected, although the incidence is greater in the Bedlington terrier, West Highland white terrier, Doberman pinscher, cocker spaniel and Skye terrier. CAH usually occurs in middle-aged animals, and females appear to be at higher risk.

Antifibrotic agents to decrease scarring in the liver

Home Care and Prevention

Administer all medications and recommended diets as directed by your veterinarian. Return for follow up examinations and biochemical evaluations.

There are no preventative measures for this disease, although performing biochemical profiles on dogs of susceptible breeds and initiating therapy in the asymptomatic stages will help slow the progression and development of serious clinical signs.

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