Glomerulonephritis in Dogs

Digg

Del.icio.us

Stumble

Glomerulonephritis in Dogs

By: Dr. Arnold Plotnick

Pages

2 3 4

Section: Overview

The kidneys consist of many thousand microscopic filtering units called glomeruli that filter water and small substances from the bloodstream. The tubules of the kidney then reabsorb vital substances such as glucose and electrolytes from the filtered fluid leaving unneeded substances and a small amount of water in the urine.

Glomerulonephritis is inflammation of these microscopic filtering units of the kidneys that develops when immune complexes (complexes of antibodies and antigens) become trapped in the glomeruli, leading to activation of the body's inflammatory defense system, which, in turn, damages the glomeruli. The immune complexes often form as a consequence of some other disease process such as infection or cancer. However, in many dogs with glomerulonephritis, the inciting cause cannot be found and the problem is said to be idiopathic.

Glomerulonephritis results in excessive loss of protein into the urine (proteinuria).

The finding of protein in the urine on urinalysis may be the first indication that your pet has glomerulonephritis. Untreated, the disease can lead to chronic kidney failure.

Dogs of any age, breed or gender can develop glomerulonephritis. In many pets, there may be no obvious symptoms of glomerulonephritis.

What to Watch For

Swelling of the abdomen

Swelling of the paws, hocks (ankles), face or scrotum

Increased water consumption

Increased urination

Weight loss

Lethargy

Vomiting

Sudden loss of vision

Sudden difficulty breathing

Diagnosis

Diagnostic tests are needed to identify acute glomerulonephritis and exclude other diseases. These may include:

Urinalysis to identify proteinuria or hyaline casts, which are protein molds of the renal tubules.

Complete blood count (CBC) to identify anemia, inflammation, infection or low platelet count.

Serum biochemistry tests to identify low blood protein concentration and high blood cholesterol concentration

Urine protein/creatinine ratio to determine the severity of protein loss in the urine

Blood pressure measurement to identify systemic hypertension

Kidney biopsy to identify glomerulonephritis conclusively and differentiate it from amyloidosis, which is another kidney disease that affects the glomeruli.

Treatment

The ideal treatment for glomerulonephritis is to identify any underlying infectious, inflammatory or cancerous disease that may be causing production of immune complexes that are being trapped in the glomeruli. Unfortunately, in many cases of glomerulonephritis, no underlying disease process can be identified, or if one can be identified, it cannot be eliminated.

Immunosuppressive drugs can be administered to suppress immune complex formation. Drugs used for this purpose are cortisone-like drugs like prednisone) and the anti-metabolite drug called azathioprine.

A very low dose of aspirin may be prescribed to prevent clotting within the glomeruli.

Specialized diets may be used in some instances.

Low protein, low phosphorus diets should be given to pets in kidney failure.

Low sodium diets should be given to pets with hypertension.

Diets supplemented with omega-3 fatty acids to limit the inflammatory response.

Medications may be prescribed to control blood pressure in pets that are hypertensive.

Drugs called angiotensin converting enzyme (ACE) inhibitors like enalapril) may be used to minimize protein loss in the urine and to help control blood pressure.

Home Care and Prevention

Administer as directed any medications prescribed by your veterinarian. Follow any dietary recommendations and schedule regular follow-up visits with your veterinarian to monitor your pet's progress.

Observation is important. Make sure your pet's activity level, appetite and attitude remain normal. Watch for difficulty breathing or limb weakness that may indicate development of thromboembolism. Observe your pet for loss of vision that could indicate complications of hypertension. Look for swelling of the paws, hocks or face that could indicate development of subcutaneous edema and for swelling of the abdomen that could indicate fluid accumulation.

Glomerulonephritis is difficult to prevent. Certain infectious, inflammatory and cancerous diseases can lead to development of glomerulonephritis and regular annual examinations by your veterinarian are advised to be certain your pet remains healthy and free of such diseases.

Pages

2 3 4

Printable Version

Digg

Del.icio.us

Stumble

Share this Article with a Friend Email To:

Have a Pet Question?

Send Your Pet Question to Dr. Jon
and His Staff of Veterinarians

Dr. Jon's Newsletter

Yes! Send Me the Latest Health Information, Pet Tips, Pet Stories and more...

Search Over 15,000 articles

1 Acute Renal (Kidney) Failure in Dogs
The kidneys filter blood, remove the waste products of metabolism, and eliminate them in the urine. Acute kidney failure (acute renal failure or ARF) is characterized by an abrupt decline in kidney function...
Read More
2 Chronic Renal (Kidney) Failure in Dogs
The digestion of food produces waste products, which are carried by blood to the kidneys to be filtered and excreted in the form of urine. When the kidneys fail, they are no longer able to remove these...
Read More

Over 10,000 Veterinarian Approved Articles

Dogs & Puppies

Dog Breeds

labrador retriever, golden retriever, yorkshire terriers, german shepherds, beagle, boxers

Dog Medication

dog allergy medication, dog pain medication, dog anxiety medication, dog flea medication

Dog Products

dog bowls, dog crates, dog toys, dog beds, dog ramps, dog food storage, dog tags

Dog Symptoms

dog vomiting, dog limping, dog diarrhea, dog bad breath, dog coughing, dog seizures

Dog Health

dog cancer, dog diabetes, dog epilepsy, dog hip dysplasia, dog health, sick dog

Dog Care

dog vaccination, dog microchipping, dog grooming, dog neutering, dog spaying, dogs mating

Dog Training

dog aggression, dog barking, dog chewing, dog behavior, dog jumping, dog whisperer

Dog Pictures

puppy pictures, funny dogs, cute dogs, dog breeds, sleeping dogs, silly dogs, small dogs

Cats

Cat Breeds

persian, siamese cats, devon rex, ragdoll cats, sphynx, maine coon cat

Cat Medication

cat flea medication, cat heartworm control, cat tick medications

Cat Products

cat litter box, cat food, cat bed, cat flea collar, cat carrier, cat urine odor

Cat Symptoms

cat vomiting, cat limping, cat diarrhea, cat bad breath, cat coughing

Cat Health

cat health, cat liver cancer, cat diabetes, cat scratch fever, cat aids, sick cat

Cat Care

cat vaccination, cat grooming, cat microchipping, cat neutering, cat spaying

Cat Behavior

cat urine marking, cat furniture scratching, cat litterbox training, cat toilet training, cat fears

Cat Pictures

cute cats, funny cats, playful cats, fat cats, jumping cats, lazy cats, sleeping cats, cute kittens

1 Acute Renal (Kidney) Failure in Dogs
The kidneys filter blood, remove the waste products of metabolism, and eliminate them in the urine. Acute kidney failure (acute renal failure or ARF) is characterized by an abrupt decline in kidney function...
Read More
2 Chronic Renal (Kidney) Failure in Dogs
The digestion of food produces waste products, which are carried by blood to the kidneys to be filtered and excreted in the form of urine. When the kidneys fail, they are no longer able to remove these...
Read More

Glomerulonephritis in Dogs

Glomerulonephritis in Dogs

Related Articles

Over 10,000 Veterinarian Approved Articles