It is vitally important to clean thoroughly all soiled areas with a professional odor neutralizer. Compounds such as Odor-Nil®, Odor-Ban®, Nil Odor®, Nature's Miracle®, and Anti Icky Poo® are just a few of the enzymatic and/or bacterial products that destroy odors at the source.
Soak the area for a sufficient time to allow the enzymes to work. Covering the area with a washcloth soaked in the solution will help delay evaporation and prolong the compounds' actions. Smooth surfaces, like linoleum floors and wood floors, are easier to clean than carpets, since the floor under the carpet must be treated as well. If the slightest trace of odor remains, your dog is likely to be attracted back to that same area to eliminate again.
Medication
If your dog does not respond to retraining, your veterinarian may chose to recommend medication, usually of the antidepressant variety, especially tricyclic antidepressants. These drugs have a side effect of causing delayed urination, which will help insure that the dog has a greater volume of urine in its bladder before it feels the urge to urinate. It will thus feel the need to urinate less frequently. However, the drugs also have a useful secondary effect of reducing anxiety, which often contributes to marking problems.
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