Lymphocytic plasmacytic enteritis (LPE) is a form of inflammatory bowel disease characterized by the presence of particular microscopic cells, including lymphocytes and plasma cells, in excess within the intestinal wall.
Causes Idiopathic, which means it has no known cause
Infectious disorders such as giardia, Salmonella, Campylobactor
Dietary agents such as meat proteins, food additives, preservatives, milk proteins and gluten (wheat)
Genetic Factors
Lymphocytic plasmacytic enteritis is seen in both dogs and cats and is seen in all ages. It is most common in middle aged and older animal.
LPE can affect all breeds, although is seen most commonly in the German shepherd, shar-pei, and Wheaton terrier.
Although some patients with LPE may have no clinical signs, some may have life threatening manifestations. Signs vary greatly in type, severity, and frequency.
What to Watch For
Diarrhea
Vomiting
Anorexia
Ravenous appetite
Lethargy
Weight loss
Abdominal distension
Difficulty breathing
Ascities, or fluid in the abdominal cavity
Edema, or abnormal fluid accumulation in any part of the body
Respiratory difficulty secondary to pleural effusion, which is fluid in the chest cavity
Diagnosis
Complete blood cell count (CBC)
Biochemical profile
Urinalysis
Fecal examinations
Thoracic (chest) and abdominal radiographs (X-rays)
Abdominal ultrasound
Gastroduodenoscopy and biopsy
Treatment
Treatment of patients with LPE should be directed at the underlying cause if identified. Most of these individuals can be treated as outpatients.
Dietary management is often recommended and varies depending on the underlying cause.
Fluid therapy may be necessary in some patients with severe vomiting and diarrhea, and is directed toward correction of dehydration and acid-base derangements, replacement of electrolyte deficits, and to provide for ongoing losses.
Diuretics, or drugs that help remove excess fluid from the body, may be indicated in some patients with LPE.
Oncotic agents are products that help maintain normal fluid distribution in the body.
Anti-inflammatory drugs
Antibiotic therapy
Home Care
Administer all medication and dietary recommendations as directed by your veterinarian. Follow up as directed by your veterinarian. If your pet's condition is not improving and is getting worse, seek veterinary attention at once.
Generally speaking, there is no preventative care for lymphocytic plasmacytic enteritis
In cases when a food intolerance or allergy is suspected or documented, avoid that particular item and adhere strictly to dietary changes.
