Naproxen Toxicity in Dogs

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Naproxen toxicity typically results from administration of an improper dose by well meaning owners or acute overdose from curious animals eating large quantities.

Naproxen belongs to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). The purpose of these drugs is to reduce the painBiocaine 4oz
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The primary reason NSAIDs are used is to reduce the presence of prostaglandins in trauma related injuries. Without prostaglandins, there is less inflammation and therefore, less pain.

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Dogs are particularly sensitive to the stomach ulcer effect of naproxen. Stomach ulcers can occur within 12 hours of ingestion but sometimes can take up to four days. Cats are more sensitive to the kidney effects of naproxen. With massive overdose or ingestion, severe kidney impairment can occur within 12 hours of ingestion but may take up to five days. In severe cases, seizures may occur.

Naproxen can result in stomach ulcers at a dose of 2.5 mg per pound (6 mg/kg) daily. Naproxen can result in kidney failure at a dose of 7 gm per pound (15 mg/kg).

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