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Section: Overview
Kidney amyloidosis is a rare disorder of protein metabolism in which abnormal deposits of protein called amyloid is deposited in the kidneys. The cause of kidney amyloidosis remains poorly understood. It is a hereditary condition in certain breeds of dog. It also may occur in other breeds or mixed breeds as a reaction to chronic infections and inflammatory conditions.Most dogs with kidney amyloidosis are old at the time of diagnosis (9 is average age). The disease can occur in any age or breed, with one study showing Beagles, collies, and walker hounds at increased risk, and German Shepherds and mixed-breed dogs at lower risk. It is a hereditary disorder in shar-pei dogs. Amyloid deposits in the kidney lead to excessive protein loss in the urine and eventual chronic kidney failure. Amyloid may also be deposited in other organs like the liver, spleen and pancreas, causing them to malfunction as well.
Nephrotic syndrome is characterized by the combination of protein in the urine, low protein level in the blood, high cholesterol and abnormal fluid accumulation in any part of the body (edema). Dogs are...
Proteinuria is the presence of excessive protein in the urine, released from the glomerulus, the filtering unit of the kidney. Normal urine contains only small amounts of protein.
The kidneys consist of many thousand microscopic filtering units called glomeruli that filter water and small substances from the bloodstream. Glomerulonephritis is inflammation of these microscopic filtering...
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