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SENTINEL® (milbemycin oxime - lufenuron)

By: Novartis Animal Health

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SENTINEL Flavor Tabs are given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10 mg/kg) lufenuron.

Recommended Dosage Schedule:

Body Weight        Milbemycin Oxime Per Tablet        Lufenuron Per Tablet
2 to 10 lbs............................2.3 mg.................................46 mg
11 to 25 lbs.........................5.75 mg...............................115 mg
26 to 50 lbs........................11.5 mg.................................230 mg
51 to 100 lbs.......................23.0 mg................................460 mg
Dogs over 100 lbs. are provided the appropriate combination of tablets

Administration:

TO ENSURE ADEQUATE ABSORPTION, ALWAYS ADMINISTER SENTINEL FLAVOR TABS TO DOGS IMMEDIATLY AFTER OR IN CONJUNCTION WITH A NORMAL MEAL.

SENTINEL Flavor Tabs are palatable and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet or tablets. Administer SENTINEL Flavor Tabs to dogs, immediately or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose has been consumed. If it is not entirely consumed, redose with the full recommended dose as soon as possible. SENTINEL Flavor Tabs must be administered monthly, preferably on the same date each month. Treatment with SENTINEL Flavor Tabs may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of mosquito and flea season. In areas with year-round infestations, treatment should continue through the entire year without interruption. To ensure the greatest flea control from the use of SENTINEL Flavor Tabs, it is important to treat all dogs and cats within a household for fleas. All cats within the household should be treated with lufenuron suspension, injectable or tablets because untreated dogs and cats may develop infestations which could reduce the overall flea control within a household (See Precautions). If a dose is missed and a 30-day interval between dosing is exceeded, administer SENTINEL Flavor Tabs immediately and resume the monthly dosing schedule. If SENTINEL Flavor Tabs replace daily diethylcarbamazine (DEC) for heartworm prevention, the first dose must be given within 30 days after the last dose of DEC.

Adverse Reactions

The following adverse reactions have been reported in dogs after giving milbemycin oxime or lufenuron: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, hypersalivation and weakness.

How Supplied

SENTINEL Flavor Tabs are available in four tablet sizes (see Dosage Section), and is formulated according to the weight of the dog. Each tablet size is available in color-coded packages of six tablets each, which are packaged 10 per display carton.

Storage Conditions

Store in a dry place at controlled room temperature, between 59° and 86°F (15°-30°C)

U.S. Patent No. 4,547,520
Manufactured for:
Novartis Animal Health US, Inc.
Greensboro, NC 27404, USA

NADA #141-084, Approved by FDA.

®2000 Novartis
NAH/SEN-FCT/VI/2
5/00

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