Cisplatin (Platinol-AQ®)
By: Dr. Dawn Ruben

Overview

Cisplatin is a drug used to treat malignant cancer. The drug, which contains platinum, affects the DNA of rapidly dividing cells but the exact mechanism of action is not clearly understood.

Due to potential serious reactions, cisplatin should not be used in cats.

As with most cancer treating drugs, cisplatin is used in combination with other drugs to enhance its ability to combat malignancy.

Due to potential damage to kidneys, dogs receiving cisplatin are usually on intravenous fluids before, during and after the drug is given.

Due to the toxic nature of cisplatin, it is given in a hospital setting. The veterinarian and assistants should wear gloves when handling the drug.

Cisplatin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.

This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug.

Brand Names and Other Names

This drug is registered for use in humans only.

Human formulations: Platinol-AQ (Bristol Myers Oncology)

Veterinary formulations: None

Use of Cisplatin

Cisplatin is used to treat various cancers such as carcinomas, nasal cancer and thyroid cancer.

Precautions and Side Effects

While generally safe and effective when prescribed by a veterinarian, cisplatin can cause side effects in some animals.

Cisplatin should not be used in animals with known hypersensitivity or allergy to the drug.

Cisplatin should be avoided in dogs with active infections, hearing impairment, kidney or liver disease.

Cisplatin should not be used in cats.

Cisplatin may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with cisplatin. Such drugs include amphotericin B and certain antibiotics.

Kidney damage, bone marrow dysfunction, loss of appetite, seizures, diarrhea and hearing loss can occur after administration of cisplatin.

Many patients will vomit immediately after the drug is given.

How Cisplatin is Supplied

Cisplatin is only available as an injection in 1mg/ml concentrations. Both 50 ml and 100 ml vials are available.

Dosing Information

Medication should never be administered without first consulting your veterinarian. Cisplatin is only administered in a hospital setting.

Cisplatin is dosed at 60 to 70 mg/m2 over 20 minutes every 3 weeks.

Dogs receiving cisplatin should be given intravenous fluids before, during and after administration.

The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.

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