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Difloxacin (Dicural®)

By: Dr. Dawn Ruben

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  • Difloxacin is a synthetic antibiotic that belongs to the fluoroquinolone class. Other related drugs include enrofloxacin and ciprofloxacin.
  • The drug inhibits bacterial enzymes, resulting in death of the bacteria.
  • Difloxacin use is reserved for serious infections and is not commonly used for minor infections.
  • Difloxain is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.

    Brand Names or Other Names

  • This drug is registered for use in animals only.
  • Human formulations: None
  • Veterinary formulations: Dicural® (Fort Dodge)

    Uses of Difloxacin

  • Difloxacin is used to treat susceptible bacterial infections.

    Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, difloxacin can cause side effects in some animals.
  • Difloxacin should not be used in animals with known hypersensitivity or allergy to the drug.
  • The drug should be used with caution in animals with CNS disorders.
  • When administered to young growing animals, fluoroquinolones have been known to cause damage to joint cartilage, resulting in lameness.
  • Difloxacin should be used with caution in small and medium sized puppies less than 8 months of age, large breed puppies less than 12 months of age and giant breed puppies less than 18 months of age.
  • Difloxacin may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with difloxacin. Such drugs include antacids, theophylline, sucralfate and certain antibiotics.
  • Adverse effects are uncommon but include vomiting, reddening of the skin, weight loss, dehydration, drooling, tremors, facial swelling, decreased appetite and decreased activity.

    How Difloxacin is Supplied

  • Difloxacin is available in 11.4 mg, 45.4 mg and 136 mg tablets.

    Dosing Information

  • Medication should never be administered without first consulting your veterinarian.
  • Difloxacin is dosed at 2.5 to 5 mg per pound (5 to 10 mg/kg) once daily.
  • The medication may need to be administered up to 30 days, especially for skin or soft tissue infections.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

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