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Ketoprofen (Ketofen®)

By: Dr. Dawn Ruben

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Overview

  • Ketoprofen belongs to a general class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). Other related drugs in this class include aspirin, ibuprofen and naproxen. These drugs are capable of reducing pain fever, and inflammation.
  • The NSAIDs work by inhibiting formation of body chemicals called prostaglandins.
  • Ketoprofen is available over the counter but should not be administered unless under the supervision and guidance of a veterinarian.

    Brand Names and Other Names

  • This drug is registered for use in humans and animals.
  • Human formulations: Orudis® (Wyeth-Ayerst), Actron® (Bayer) and Oruvail® (Wyeth-Ayerst)
  • Veterinary formulations: Ketofen® (Fort Dodge)

    Uses of Ketoprofen

  • Ketoprofen is primarily used to treat pain and inflammation associated with arthritis and other musculoskeletal disorders.
  • It is also used in the postoperative period to reduce pain associated with surgical procedures.

    Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, ketoprofen can cause side effects in some animals.
  • Ketoprofen should not be used in animals with known hypersensitivity or allergy to the drug.
  • Ketoprofen should be avoided in animals with liver, heart or blood abnormalities.
  • Ketoprofen should also be avoided in animals with gastrointestinal disorders, including ulcers.
  • Ketoprofen may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with ketoprofen. Such drugs include aspirin, other NSAIDs, corticosteroids and heparin.
  • The most common adverse effects associated with ketoprofen are vomiting, diarrhea, lethargy and lack of appetite.
  • Stomach ulcers and kidney impairment are possible.

    How Ketoprofen Is Supplied

  • Ketoprofen is available in 12.5 mg, 25 mg, 50 mg and 75 mg tablets and as 100 mg, 150 mg and 200 mg extended-release tablets.
  • It is also available in a 100 mg/ml injectable form.

    Dosing Information

  • Medication should never be administered without first consulting your veterinarian.
  • Initially, ketoprofen is dosed at 1 mg per pound (2.2 mg/kg) once, then at 0.5 mg per pound (1 mg/kg) daily.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse.




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