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Orbifloxacin (Orbax®)

By: Dr. Debra Primovic

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  • Orbifloxacin is a broad-spectrum antibiotic used to treat infections in animals caused by susceptible bacteria.
  • Orbifloxacin inhibits the synthesis of bacterial DNA, resulting in death of the bacteria.
  • Orbifloxacin belongs to a general class of drugs known as fluoroquinolone antibiotics. Other related drugs in this class include enrofloxacin (Baytril®), ciprofloxacin and marbofloxacin.
  • Orbifloxacin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.

    Brand Names or Other Names

  • This drug is registered for use in animals only.
  • Human formulations: None
  • Veterinary formulations: Orbax® (Schering-Plough)

    Uses of Orbifloxacin

  • Orbifloxacin is used to treat a variety of infections, including skin infections, urinary tract infections, respiratory infections and wound infections caused by susceptible bacteria. While orbifloxacin is highly effective, some microorganisms are resistant to its effects.
  • Orbifloxacin is not effective for treating infections caused by viruses, anaerobic bacteria, rickettsial microorganisms, parasites (worms and mites) or fungi (molds and yeasts).

    Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, orbifloxacin can cause side effects in some animals.
  • Orbifloxacin should not be used in animals with known hypersensitivity or allergy to the drug.
  • Orbifloxacin has a good safety record and adverse reactions are uncommon. Occasionally, some animals develop diarrhea or loose stools from orbifloxacin treatment.
  • Young animals treated with orbifloxacin may develop damage to the cartilage of their joints. Swollen joints and lameness are clinical signs that may be observed. Accordingly, orbifloxacin should not be administered to puppies. Those between the ages of four and 28 weeks are the most susceptible.
  • Orbifloxacin should be used with caution in dogs or cats with central nervous system abnormalities (such as seizures or epilepsy).
  • Orbifloxacin may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with orbifloxacin. Such drugs include stomach protectants and antacids.

    How Orbifloxacin Is Supplied

  • Orbifloxacin is available in tablets of 5.7 mg, 22.7 mg and 68 mg.

    Dosing Information

  • Medication should never be administered without first consulting your veterinarian.
  • The typical dose administered to dogs and cats is 1.25 to 3.25 mg per pound (2.5 to 7.5 mg/kg per day) orally once a day.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

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