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Tepoxalin (Zubrin®)

By: Dr. Debra Primovic

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  • Tepoxalin belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs).
  • Tepoxalin provides dual action (Cox1/Cox 2 and LOX) inhibition for treatment of pain and inflammation associated with canine osteoarthritis.
  • Tepoxalin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
  • This drug is approved for use in dogs by the Food and Drug Administration.

    Brand Names and Other Names

  • Veterinary formulations: Zubrin® (Schering-Plough)
  • Human formulations: None

    Uses of Tepoxalin

  • Tepoxalin is used in the treatment pain associated with inflammation, e.g. osteoarthritis in dogs.

    Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, tepoxalin may cause side effects in some dogs.
  • Tepoxalin should not be used in dogs with known hypersensitivity or allergy to the drug.
  • The safety of tepoxalin has not yet been determined in breeding, pregnant, or lactating dogs or in dogs less than 6 months of age.
  • Tepoxalin should be avoided in animals with a history of bleeding, inflammation, or perforation of the stomach wall or intestinal mucosa (lining). Also, it should be avoided in animals that are dehydrated or have low blood pressure.
  • This drug must be used with caution in patients with heart failure, liver disease, kidney disease, or a history of adverse side effects with other NSAID's.
  • Until more studies are completed, tepoxalin should not be used in cats.
  • According the manufacturer (Schering-Plough), in a target animal safety study, dogs dosed with Tepoxalin at 30 times the recommended daily dose for 28 days showed no significant increase in liver enzymes or kidney parameters and showed no gastrointestinal ulcers.
  • Tepoxalin may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving might interact with tepoxalin. Such drugs include aspirin, corticosteroids (for example prednisone, cortisone, dexamethasone or triamcinolone), and other NSAID's (for example carprofen, phenylbutazone or etodolac).
  • Side effects of tepoxalin include stomach and intestinal ulcers, intestinal bleeding, dark or tarry stools (from bleeding into the intestines), vomiting, loss of appetite, and peritonitis (from intestinal perforation). Some of these side effects are life threatening when extreme.
  • The potential for ulcers increases when tepoxalin is used in combination with corticosteroids (such as cortisone or prednisone), aspirin, or phenylbutazone.
  • As with other NSAIDs, tepoxalin may cause liver, kidney, or blood clotting abnormalities.

    How Tepoxalin Is Supplied

  • Tepoxalin is available in 30 mg, 50 mg, 100 mg and 200 mg rapidly-disintegrating tablets.

    Dosing Information

  • Medication should never be administered without first consulting your veterinarian.
  • For its anti-inflammatory effect, tepoxalin is dosed at 4.5 mg per pound (10 mg/kg) once daily for a maximum of four weeks. An initial one-time dose of 9.1 mg/lb (20 mg/kg) is sometimes employed, followed by 10 mg/kg once daily dosage.
  • Labeled for use in dogs only.
  • Tepoxalin is a "rapidly-disintegrating" tablet that dissolves quickly upon contact with saliva in dogs' mouths. It is therefore is difficult to "spit out." According to the manufacturer, dogs' mouths should be held closed for several seconds (4 to 5 seconds) after dosing to ensure dispersion of the medication.
  • Tepoxalin should be given with food or within 1 – 2 hours of feeding.
  • The duration of administration of tepoxalin depends on the condition being treated, response to the medication, and the development of any adverse effects. Be certain to complete the prescription unless specifically directed otherwise by your veterinarian. Even if your pet appears to be feeling better, the entire treatment plan should be completed to prevent relapse.

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