Simethicone (Gas-X) for Dogs and Cats
Overview of Simethicone
- Simethicone, commonly known as Gas-X® and several other names (see below under “Brand Names and Other Names”), is an anti-foaming and anti-flatulent agent used to treat discomfort, pain, bloating, burping, and flatulence caused by excessive intestinal gas in dogs and cats.
- Simeticone works by decreasing the surface tension of gas bubbles which allows the small bubbles to form into larger bubbles. The larger bubbles are more easily eliminated by burping or passing intestinal gas (flatus). It causes the collapse of foam bottles. Simeticone does not appear to decrease the production or formation of gas but works by improving gas elimination from the gastrointestinal tract.
- Simethicone is available over the counter, but should not be administered unless under the supervision and guidance of a veterinarian.
Quick Answer: For dogs, simethicone (Gas-X) is typically dosed at 25–200 mg every 6–12 hours, depending on size, while cats often receive 0.3–0.5 mL of liquid simethicone every 8–12 hours as needed. Always consult your veterinarian before administering simethicone to ensure appropriate dosing and to rule out serious conditions like bloat or gastrointestinal obstruction.
Brand Names and Other Names for Simethicone
Simeticone is marketed under several different brand names and in combination with many drugs in both human and veterinary medicine.
- Human formulations: Alka-Seltzer Anti-Gas; Anti-Gas Ultra Strength; Baby Gasz; Equilizer Gas Relief; Gas Aid Maximum Strength; Gas-X; Genasyme; Maalox Anti-Gas; Mylanta Gas; Mylicon; Mytab Gas; and Phazyme.
- Simeticone COMBINATION products may include:
- Alamag Plus® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Aldroxicon® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Balanta® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Dixlanta® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Flatulex® Tablets (containing Activated Charcoal, Simethicone)
- Gas-X® with Maalox ® (containing Calcium Carbonate, Simethicone)
- Gelusil® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Gen-Lanta (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Imodium® Advanced (containing Loperamide, Simethicone)
- Losospan® Plus (containing Magaldrate, Simethicone)
- Low Sodium Plus® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Lowsium Plus® (containing Magaldrate, Simethicone)
- Maalox® Plus (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Magaant® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Magagel® Plus (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Magaldrate Plus (containing Magaldrate, Simethicone)
- Magalox® Plus (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Maldroxal® Plus (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Masanti® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Mygel® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Mylagel® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Mylagen® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Mylanta® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Ri-Gel II® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Ri-Mox® Plus (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Riopan® (containing Magaldrate, Simethicone)
- Rolaids® Multi-Symptom (containing Calcium Carbonate, Magnesium Hydroxide, Simethicone)
- Rolaids® Plus Gas Relief (containing Calcium Carbonate, Simethicone)
- Rulox® Plus (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone)
- Titralac® Plus (containing Calcium Carbonate, Simethicone)
- Veterinary formulations: Various
Uses of Simethicone for Dogs and Cats
- Simethicone is used to treat discomfort, pain, bloating, burping, and flatulence caused by excessive intestinal gas. When used to treat flatulence in dogs, it is most effective when combined with dietary modifications. Get more tips on how to treat flatulence in dogs here. It is sometimes used to break up gas production in dogs at risk of or in conjunction for treatment of “Bloat”, also known as Gastric Dilatation-Volvulus.
- Simethicone may be given by veterinarians prior to abdominal radiographs (X-rays) or gastrointestinal endoscopy to optimize organ visualization.
Comparison with Other Anti-Gas Options
While simethicone effectively reduces gas discomfort by collapsing gas bubbles in the gastrointestinal tract, other treatments like activated charcoal and famotidine serve different purposes. Activated charcoal primarily adsorbs toxins and may reduce gas odor but is less effective for gas volume and discomfort, as its binding capacity can be depleted before reaching the large intestine.
Famotidine, an H2 blocker, decreases stomach acid production and is more suited for conditions like acid reflux or ulcers rather than gas relief. Therefore, for immediate relief from gas-related discomfort, simethicone remains a preferred option, while the others are used based on specific underlying conditions.
Precautions and Side Effects
- While generally safe and effective when prescribed by a veterinarian, Simethicone can cause side effects in some animals.
- Simethicone should not be used in animals with known hypersensitivity or allergy to the drug.
- If your dog is showing signs of restlessness, large abdomen, and/or nonproductive vomiting, please see your vet as soon as possible. These symptoms could be caused by a potentially life-threatening condition called Gastric Dilatation-Volvulus (Bloat).
- The most common side effects of Simethicone in dogs and cats are diarrhea, nausea, vomiting, and lethargy.
- The safety of Simethicone use in pets pregnant or lactating has not been established, however, it is considered safe for use by many veterinarians.
- Simethicone is commonly used with other medications including antibiotics and those for nausea.
- Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Simethicone.
Simethicone FAQ
Is simethicone safe for puppies and kittens?
Simethicone is generally considered safe for puppies and kittens, but always consult your veterinarian for appropriate dosing based on age and weight.
How fast does Gas-X (simethicone) work in dogs?
Simethicone typically starts working within 30 to 60 minutes to relieve gas discomfort in dogs.
Can I give my cat Gas-X for bloating or gas?
Yes, cats can receive simethicone (usually in liquid form), but consult your vet to ensure correct dosing and to rule out serious issues.
What are the signs that my dog needs simethicone?
Signs include abdominal bloating, discomfort, excessive gas, or burping—though these can also indicate more serious conditions requiring veterinary attention.
Can simethicone be given with other medications?
Simethicone is usually safe to combine with other medications, but you should always check with your vet to avoid interactions or masking serious symptoms.
How Simethicone Is Supplied
- Simethicone is available in multiple forms and strengths that include but are not limited to tablets, chewable tablets, liquid, capsules, syrup, suspension, solution, and fluid-filled capsules.
- Most formulations of Simethicone can be stored at room temperature.
Dosing Information of Simethicone for Dogs and Cats
Pet Weight | Dog Dose (Simethicone) | Cat Dose (Liquid Simethicone) |
≤15 lb (small dogs and cats) | 25 mg every 6–12 hours | 0.3–0.5 mL every 8–12 hours |
16–30 lb (medium dogs) | 40–80 mg every 6–12 hours | N/A |
31–40 lb (large dogs) | 80–125 mg every 6–12 hours | N/A |
41–60 lb (larger dogs) | 125–150 mg every 6–12 hour | N/A |
Over 60 lb (giant breeds) | 150–200 mg every 6–12 hours | N/A |
- Medication, even over-the-counter (OTC) medication such as Simethicone, should never be administered without first consulting your veterinarian. If you’re concerned about costs related to medication, pet insurance may be able to help. Click here to learn more.
- In dogs, the dose of Simethicone recommended for treatment of excessive gastrointestinal gas ranges from 25 mg total dose for small dogs and up to 200 mg total dose for large dogs every 6 to 12 hours as needed.
- In cats, the liquid formulations are most often used with doses that range from 0.3 mL to 0.5 mL every 8 to 12 hours as needed.
- The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.
- Can be stored at room temperature. Keep away from light and moisture.
Resources & References:
- Plumb’s Veterinary Handbook by Donald C. Plumb, 8th Edition
- Textbook of Veterinary Internal Medicine, Ettinger & Felman
- Current Veterinary Therapy XV, Bonagura, and Twedt
- ASPCA Pet Poison Hotline
- Pet Poison Helpline