Cholangiohepatitis in Cats


Overview of Feline Cholangiohepatitis 

Cholangiohepatitis is an inflammation of the biliary structures (the system that carries bile) and the surrounding liver tissue. In the cat it occurs in several forms, including suppurative cholangiohepatitis, nonsuppurative cholangiohepatitis, and biliary cirrhosis. In the suppurative form of the disease, white blood cells called neutrophils are commonly seen in biopsies. In the nonsuppurative form of the disease, white blood cells called lymphocytes and plasma cells are most commonly seen on biopsy. With cirrhosis, extensive scarring is found in both the biliary system and the liver.

This is a syndrome seen primarily in cats and infrequently in dogs. All breeds of cats can be affected, although the incidence is greater in the Himalayan, Persian, and Siamese cat. Cholangiohepatitis usually occurs in middle-aged animals, and males appear to be at higher risk for the suppurative form.

Causes of Suppurative Cholangiohepatitis

  • Ascending bacterial infection from the intestinal tract, which may be associated with other diseases such as bacterial and parasite infections and pancreatitis.
  • Infections carried through the blood stream (blood-borne), such as bacterial (e.g. Salmonella), parasitic (e.g. toxoplasmosis), and viral (e.g. feline infectious peritonitis virus) infections
  • Causes of Nonsuppurative Cholangiohepatitis

    This type of cholangiohepatitis is thought to be an immune disorder associated with the following conditions:

  • Cholecystitis (inflammation of the gallbladder)
  • Cholelithiasis (stones in the gallbladder)
  • Pancreatitis (inflammation of the pancreas)
  • Extrahepatic biliary obstruction (blockage of the bile duct outside the liver)
  • Inflammatory bowel disease
  • Chronic interstitial nephritis (an inflammatory disorder of the kidney)
  • Idiopathic (unknown causes)
  • What to Watch For

  • Fever
  • Loss of appetite
  • Dehydration
  • Vomiting, diarrhea
  • Jaundice (yellow color to the skin)
  • Lethargy, collapse
  • Ascites (fluid in the abdomen)
  • Weight loss
  • Disorientation, blindness, seizures, excessive salivation associated with severe liver disease
  • Diagnosis of Cholangiohepatitis in Cats

    Diagnosis of cholangiohepatitis can be difficult and often requires the use of multiple diagnostic tests. Your veterinarian may refer your cat to a specialist in veterinary internal medicine for further evaluation. Tests that may be needed to reach the diagnosis and to determine the severity of the disease, include the following:

  • A complete blood count (CBC), biochemical profile and urinalysis
  • A coagulogram (clotting profile) to test the ability of the blood to clot
  • Serum bile acids to determine how severe the liver is changed
  • Ammonia levels, especially if the cat is disoriented or blind
  • Abdominal radiographs (X-rays)
  • Abdominal ultrasound
  • Blood tests for toxoplasmosis, feline infectious peritonitis and other viral infections
  • Exploratory laparotomy (abdominal surgery) to examine the liver, gall bladder and associated structures
  • Laparoscopy to allow visualization and sampling of abdominal structures through a scope introduced through a tiny incision in the abdominal wall
  • Liver biopsy with bacterial culture and sensitivity testing to confirm the diagnosis
  • Treatment of Cholangiohepatitis in Cats

  • Hospitalization and supportive care (fluid and electrolyte therapy) as needed for dehydration from severe vomiting, diarrhea, and anorexia
  • Treatment of any underlying medical disorders
  • Antibiotic therapy
  • Immune modulating drugs (drugs that alter the immune system) for the nonsuppurative form of the disease
  • Nutrition and dietary management
  • Vitamin supplementation
  • Diuretics to help the body eliminate excess abdominal fluid)
  • Choleretic drugs to enhance the flow of bile
  • Lactulose to slow the absorption of ammonia from the colon so that the diseased liver does not have to process so much ammonia
  • Surgery may be indicated to address underlying causes such as cholecystitis (removal of gall bladder), cholelithiasis (removal of gall stones), and extrahepatic biliary obstruction (surgical correction of the obstruction).
  • Home Care and Prevention

    Therapy is often required long-term and numerous evaluations may be required to determine the response to therapy. Administer all medication and recommended nutritional supplements as directed by your veterinarian. Return for follow up examinations and biochemical evaluations.

    There are no preventative measures recommended in these patients; however, controlling inflammatory bowel disease may be of benefit in some cases.

    In-depth Information on Cholangiohepatitis in Cats

    Cholangiohepatitis is an inflammatory disorder of the bile ducts and adjacent liver tissue. It is one of the more common liver diseases seen in cats and is recognized only infrequently in dogs. Most cats have few clinical signs early in the disease process, although they may develop a variety of severe and often life-threatening clinical signs as the process progresses.

    The disorder is generally subdivided into several types, based on the biopsy findings within the liver.

  • Suppurative cholangiohepatitis may arise with infections, usually bacterial in nature. This type has an acute (rapid) onset and is often associated with severe and devastating symptoms.
  • Nonsuppurative cholangiohepatitis, which is usually associated with a more chronic (long-term), insidious course where clinical signs may be mild and vague for weeks or months before the cat is brought in for evaluation. The nonsuppurative form is thought to involve an immune-mediated mechanism secondary to other disorders.
  • Biliary cirrhosis. This form is characterized by severe scarring in the biliary system and liver and may be the final end-stage of the other two forms of the disease.
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