Colitis (Inflammation of the Colon) in Cats


Veterinary care should include diagnostic tests and subsequent treatment recommendations.

Diagnosis In-depth

Diagnostic tests are needed to identify colitis and exclude other diseases that may cause similar symptoms. Tests may include:

  • A complete medical history and thorough physical examination (including a digital rectal examination and thorough abdominal palpation) are the first steps in establishing an accurate diagnosis.
  • Several fecal studies designed to evaluate for the presence of parasite worm eggs and protozoa (fecal flotation, direct fecal smear, and zinc sulfate tests for Giardia and Balantidium) should be performed in all cats with suspected colitis. Parasitism is one of the most common causes and contributing factors in cats with colitis.
  • A complete blood count (hemogram or CBC) may identify a high white blood cell count in infectious and inflammatory disorders and may disclose anemia due to chronic blood loss in the stool in some forms of colitis.
  • Serum biochemistry tests usually are normal in cats with colitis, but such tests help identify abnormalities of other body systems (pancreas, liver) that may cause similar symptoms. These tests also help determine the general health of your cat.
  • Urinalysis may be performed to evaluate kidney function.
  • Abdominal X-rays usually are normal but may disclose evidence of abnormalities in other organs (lymph nodes, prostate gland) that may be pressing on the colon and causing symptoms of colitis.
  • Chest X-rays often are recommended in older cats and in those suspected to have cancer so as to evaluate for spread (metastasis) of the tumor to the lungs.
  • Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) tests are performed on all cats with signs of systemic illness.
  • Serum thyroid hormone concentration often is checked in older (those greater than 6 years of age) cats because vomiting and diarrhea can be symptoms of hyperthyroidism.

    Your veterinarian may recommend additional diagnostic tests to ensure optimal medical care if the previous tests were not conclusive. These are selected on a case-by-case basis. Tests may include:

  • A barium enema (in which a radiographic contrast dye is placed directly into the colon followed by X-rays of the abdomen) sometimes is recommended to identify masses or changes in the colon that would be difficult to visualize on plain abdominal X-rays. This procedure is cumbersome to perform and often uncomfortable for the cat. Consequently, it is not frequently performed.
  • Ultrasound examination of the abdomen allows internal organs such as the colon, regional lymph nodes, and prostate gland in males to be visualized and evaluated with minimal discomfort to the cat. Abnormal tissues may be sampled with a needle or biopsy instrument with the guidance of ultrasound. Abdominal ultrasound examination often is performed by a veterinary radiologist or a veterinary specialist in internal medicine and may require referral.
  • Examination of the colon (after withholding food and performing several cleansing enemas) with a flexible fiberoptic endoscope allows direct visualization of the inside surface of the colon so that polyps, tumors, chronic inflammation and occasionally parasites can be identified. During this procedure, several small biopsies of the inner surface of the colon can be taken and submitted for microscopic examination by a veterinary pathologist. Only brief hospitalization is required for colonoscopy but this procedure may require referral to a specialist in veterinary internal medicine. Colonoscopy usually is performed after routine tests have been inconclusive and the cat has not responded to conservative treatment such as anti-parasitic medications and dietary modification.
  • Treatment In-depth

    Many treatments are available for cats with colitis. If at all possible, a specific cause for colitis should be identified so that proper treatment can be instituted. In otherwise healthy cats with colitis, outpatient treatments such as anti-parasitic medications or dietary modification may be recommended initially. If this approach is unsuccessful, additional tests (including colonoscopy and biopsy) are recommended to improve the chance of a specific and accurate diagnosis. Complete resolution of clinical symptoms may not be possible, even with an accurate diagnosis and proper treatment.

    Treatments for colitis may include one or more of the following:

  • A 24 to 48 hour fast with gradual introduction of a bland diet followed by gradual re-introduction of the cat’s normal diet may be sufficient treatment for many cats with acute colitis.
  • In cats with chronic colitis, dietary modification using hypoallergenic diets may be tried. Using a home-prepared or commercial diet that contains a “novel” protein source (one which the cat has not previously encountered) sometimes is sufficient to control the colitis and eliminates the need for further medical treatment. No food items except for the “hypoallergenic” diet should be fed to affected cats during this trial period of treatment. Cats that respond to this approach are thought to have a food allergy that is manifested as colitis.
  • Fiber supplementation (either by adding fiber to the cat’s normal diet or choosing a diet that is naturally high in fiber) sometimes is of great benefit to cats with colitis.
  • Anti-parasitic (deworming products, anti-protozoal drugs) treatment is indicated in cats with colitis to eliminate the possibility of parasites that are intermittently shed in the stool (Giardia). Parasites are a leading causes of colitis in cats, and this approach is routinely taken be done as a first step in the management of colitis.
  • Antibiotic treatment can play an important role in the management of colitis in cats. Although useful when a bacterial cause of colitis has been identified, antibiotics are sometimes useful even when a bacterial cause of colitis has not been established. Three anti-microbial agents commonly used in this situation are metronidazole, sulfasalazine and tylosin. These drugs have been used successfully as single agents, in combination with one other, or in combination with other drugs.
  • Anti-inflammatory and immunosuppressive drugs (drugs that suppress the immune system) such as cortisone-like drugs (corticosteroids) and immunosuppressive drugs generally are reserved for cats in which colitis is strongly suspected to be immune-mediated in nature based on microscopic examination of biopsy specimens obtained during colonoscopy. These drugs have potential adverse effects and only should be used under close veterinary guidance with regularly scheduled re-evaluations of the cat. These drugs are invaluable and extremely effective when used appropriately.
  • Motility-modifying drugs (drugs that effect the motor activity of the intestinal tract) most often are used for symptomatic relief rather than for long-term medical management of cats with colitis.
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