Hepatic Encephalopathy in Cats

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Overview of Feline Hepatic Encephalopathy

Hepatic encephalopathy (HE) is a degenerative disease of the brain caused by severe hepatic insufficiency in advanced liver disease. It is characterized by abnormal mental status, an altered state of consciousness and impaired neurologic function.

The most common cause is a congenital abnormality present at birth called a portosystemic shunt. This is an anatomical defect that causes blood to be diverted around the liver instead of passing through the liver. The liver cannot detoxify the blood and the toxins reach the brain and cause the clinical syndrome. Patients with liver failure due to toxic or infectious causes can also exhibit signs of HE.

There is no age, sex, or breed predisposition for animals with toxic or infectious liver disease; however, animals with congenital portosystemic shunts are usually brought to the veterinarian within the first year of life.

What to Watch For

The clinical manifestations of HE can range from mild (unusual behavior) to severe (coma).

  • Hysteria
  • Unpredictable bouts of aggression
  • Staggering
  • Pacing
  • Compulsive circling
  • Pressing the head against a wall
  • Sudden apparent blindness
  • Tremors
  • Seizures
  • Coma-like state

    These unusual behavior changes are often more pronounced a short time after a meal.

    Also watch for:

  • Anorexia
  • Lethargy
  • Weight loss
  • Drinking a lot or urinating a lot
  • Nausea or hypersalivation (drooling)
  • Vomiting
  • Diarrhea
  • Diagnosis of Hepatic Encephalopathy in Cats

    Hepatic encephalopathy is a syndrome and not a disease itself. It is diagnosed by a combination of the patient’s history, physical examination findings and laboratory data. These findings can support the presence of significant liver disease in an animal in which no other cause for the neurologic and behavioral signs can be identified. Tests that help make the diagnosis of severe liver disease and resultant HE include:

  • Complete blood count
  • Serum chemistry panel
  • Urinalysis
  • Blood clotting profile
  • Blood ammonia level or ammonia tolerance test
  • Bile acid test
  • Abdominal radiographs or special dye studies
  • Abdominal ultrasound
  • Liver biopsy
  • Transcolonic scintigraphy

    Treatment of Hepatic Encephalopathy in Cats

  • Remove the predisposing cause, if possible
  • Antibiotics
  • Lactulose
  • Diet
  • Home Care and Prevention

    When at home, administer proper diet and medications as prescribed. Watch your cat for any of the signs listed above.

    One can minimize exacerbations of clinical signs of HE by avoiding some predisposing factors:

  • Don’t feed high protein meals
  • Avoid drugs that might induce gastrointestinal bleeding, such as aspirin
  • Avoid giving tranquilizers or sedatives for travel
  • Avoid organophosphate insecticides
  • In-depth Information on Hepatic Encephalopathy in Cats

    Hepatic encephalopathy is a neuropsychiatric disorder that occurs in animals and people with advanced liver disease. In cats, it is most often seen when blood is diverted or shunted around the liver, called portosystemic shunting. Blood can be diverted around the liver because of a congenital shunt present at birth or an acquired shunt that occurs secondary to long-term liver disease.

    HE is often manifested as a wide range of neurologic abnormalities. The first signs are usually behavioral. At first, the changes are subtle, and they may wax and wane. As the disorder progresses, the signs become more obvious. Signs may be precipitated by a meal. As the syndrome becomes more apparent, cats usually has a few bad days, alternating with days in which the cat is acting fairly normal.

    While any severe liver disease can lead to HE, portosystemic shunts are the most likely disorder to produce signs of HE; approximately 95 percent of animals with portosystemic shunts show signs of HE. In decreasing order of frequency, these signs are:

  • Depression
  • Personality changes
  • Drooling
  • Stupor
  • Pacing or circling
  • Staggering or incoordination
  • Blindness
  • Collapse or weakness
  • Seizures
  • Head pressing
  • Hyperactivity
  • Head or muscle tremors
  • Deafness
  • Coma

    There are several theories as to what actually causes the neurologic signs that are seen when the liver is not able to function properly. However, ammonia has always been implicated as one of the important toxins that contribute to neurologic signs. The liver converts ammonia into urea. When the liver is too diseased to do this properly, or if blood containing high levels of ammonia bypasses the liver because of a shunt, the ammonia circulates in high levels in the blood stream, and this affects the brain, causing the neurologic signs described.

    A grading system has been modified from human medicine, for use in animals. In this system animals with HE are graded on a scale of 1 to 4.

  • Grade 1. Animal shows listlessness, depression, mental dullness, personality changes, excessive urination.
  • Grade 2. Animal shows incoordination, disorientation, compulsive pacing or circling, head pressing, apparent blindness, personality changes, salivation and excessive urination.
  • Grade 3. Stupor, severe salivation and seizures, although uncommon, are present.
  • Grade 4. Coma
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