Hepatic Lipidosis in Cats


Overview of Fatty Liver Disease in Cats

Hepatic lipidosis, commonly called fatty liver disease, is a syndrome characterized by an accumulation of excessive amounts of lipid (fat) within the cells of the liver, abnormal bile flow within the liver, and impaired liver function. Severe impairment of liver function may affect the liver’s ability to detoxify the blood. As toxins accumulate, they can affect the mental status of the cat, leading to mental dullness, severe depression, and seizures. Hepatic lipidosis can occur as a primary event, or it can occur secondary to other disease processes, such as diabetes. It is the most common liver disease encountered in cats.

Below is an overview on Fatty Liver Disease in Cats followed by in-dpth information on the diagnosis and treatment of this disease. 

Adult cats of either sex can be affected. Any breed of cat is susceptible. Middle aged to older cats are most likely to be affected. Hepatic lipidosis can be a serious disease. Even with aggressive therapy, a significant number of cats die from the condition.

The cause of hepatic lipidosis remains unknown. Obesity is thought to be a predisposing factor, as most (but not all) affected cats are obese at the time of disease onset. A period of anorexia (decreased appetite), occurring as a result of a stressful event (such as the addition of a new pet or family member, or a sudden change to a less palatable diet) can trigger the onset of hepatic lipidosis.

What To Watch For

  • Anorexia
  • Loss of muscle mass
  • Vomiting
  • Drooling
  • Jaundice (yellow tint to the whites of the eyes and possibly the skin inside the ears)
  • Severe depression
  • Possible seizures
  • Diagnosis of Fatty Liver Disease in Cats

    The diagnostic tests needed to confirm the presence of hepatic lipidosis and exclude other liver disorders include:

  • Complete medical history and physical exam. This includes examination of the gums, whites of the eyes, and other part of the body for jaundice (yellow discoloration).
  • Blood tests and urine analysis to confirm that the liver is affected
  • Bile acid test to assess how well the liver is functioning
  • Abdominal x-rays to evaluate the liver
  • Abdominal ultrasound. This is a painless procedure in which a probe is held against the abdomen and is used to detect valuable information about the health of the liver.
  • Fine-needle aspirate of the liver. This technique allows for a small sample of liver cells to be obtained and evaluated.
  • Liver biopsy. Obtaining a biopsy specimen (a small piece of the liver) is the definitive test for making a diagnosis of hepatic lipidosis.
  • Treatment of Fatty Liver Disease in Cats

    Dietary therapy is the mainstay of treatment. Affected cats may need to be force fed, or fed through a tube in the nose, esophagus, or stomach. Hospitalization is usually required for the first few days. Treatment for hepatic lipidosis may also include some or all of the following:

  • Medication to control vomiting
  • Drugs that help control gastrointestinal bleeding for cats that develop stomach ulcers
  • Medications that help control the mental signs of hepatic lipidosis in severe cases
  • Blood transfusion if the impaired liver cannot normally regulate blood clotting
  • Appetite stimulants
  • Drugs to improve bile flow within the liver
  • Home Care and Prevention

    Follow all feeding instructions very carefully, as dietary therapy is the most important aspect of therapy.

    If a nasal, esophageal, or stomach feeding tube has been inserted, follow all instructions as to the care and maintenance of this tube, and report any problems to your veterinarian immediately.

    Give all medications and dietary supplements as directed.

    Although the actual cause of the disorder is unknown, obesity and anorexia have been noted to be associated with the onset of disease. Therefore avoid overfeeding your cat to prevent obesity and avoid stressful situations that may cause a cat to suddenly stop eating, such as the addition of a new pet or family member, or suddenly changing your cat’s diet.

    In-depth Information on Fatty Liver Disease in Cats

    Hepatic lipidosis (fatty liver disease) is a common disease of the feline liver in which abnormally large amounts of lipid (fat) accumulates within the cells of the liver. In other animals (humans, dogs, laboratory animals), lipid accumulation tends to be harmless, however, the cat’s unique pathways of protein and fat metabolism cause lipid accumulation in the liver to have severe consequences. Any breed of cat may be affected, and both sexes seem to be affected equally. Middle aged to older cats are more susceptible than young cats.

    Most, but not all, affected cats have a history of being obese, as well as a history of a sudden loss of appetite, often precipitated by a stressful event, such as a move to a new home, separation from an owner, a new pet or family member in the household, or a sudden switch to an unpalatable food. Anorexia, depression, and intermittent vomiting are the first signs usually noted by the cat owner. As liver function worsens, cats may develop jaundice (a yellow discoloration to the whites of the eyes, gums, and skin), severe loss of muscle mass, drooling, and signs of mental dysfunction (severe depression, sudden blindness, seizures). Cats often lose at least 25 percent of their body weight. The diagnostic tests recommended will help differentiate hepatic lipidosis from other liver diseases such as:

  • Cholangiohepatitis – an infection or inflammation of the liver and bile ducts
  • Feline infectious peritonitis – a deadly viral disease that can affect many organs, including the liver
  • Toxic liver disease – caused by ingestion of a drug or other harmful toxin
  • Liver cancer
  • Feline leukemia virus
  • Parasites – such as liver flukes (uncommon)
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