What is the Difference between Prednisone and Prednisolone for Cats and Dogs?

Dr. Debra,

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My cat was given Prednisolone but my vet verbally said they were going to start Prednisone. What is the difference? Which is better for my cat? Is there a difference using Prednisolone vs. Prednisone? Is the dose the same?

Thanks for your help.

Barbara K., Atlanta, GA

Dear Barbara,

Thanks for your question. Prednisone and Prednisolone are corticosteroid drugs commonly used to treat allergies, inflammations, autoimmune diseases and cancers.

Prednisone is converted to prednisolone readily in dogs but not as well in some cats, therefore Prednisolone is preferred in cats when possible. Prednisolone is the active form of the drug used by the body.

When Prednisone is used instead of Prednisolone, sometimes a slightly higher dose is used in cats.

For more information on this drug and dosages, visit our drug library article Prednisone and Prednisolone for Dogs and Cats.

Best of Luck,

Dr. Debra