Grapiprant (Galliprant®) for Dogs

Grapiprant, most commonly known by the brand name Galliprant®, is an anti-inflammatory and analgesic drug commonly used in dogs. It belongs to the class of drugs known as a first-in-class piprant; a non-COX-inhibiting prostaglandin receptor antagonist (PRA).

  • Galliprant works by blocking the specific receptor, the EP4 receptor, the main mediator of osteoarthritis pain and inflammation in dogs.
  • Galliprant is commonly compared to or used as an alternative to the class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Drugs in this class include Celebrex®, ibuprofen, carprofen (Rimadyl®), Deracoxib (Deramaxx®), aspirin and naproxen. Drugs in this class are associated with side effects relative to kidney and liver function and therefore Galliprant is commonly used as a safer alternative in some dogs with underlying liver or kidney disease that require pain management.
  • Galliprant® is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.

Brand Names and Other Names of Deracoxib

  •   This drug is registered for use in animals only.
  •   Human formulations: None
  •   Veterinary formulations: Galliprant® (Elanco)


Uses of Deracoxib for Dogs

  • Galliprant® is indicated for the control of pain and inflammation associated with orthopedic pain from osteoarthritis in dogs.
  • Galliprant® can also be used for chronic pain management.

Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, Galliprant® can cause side effects in some animals. The most common side effects are decreased appetite, vomiting, soft mucoid stools, and/or diarrhea. Please contact your veterinarian if you see these signs in your dog while giving Galliprant®.
  • Galliprant® should not be used in dogs with known hypersensitivity or allergy to the drug or other drugs in this class.  Signs of an allergic reaction to Galliprant® may include hives, itchy skin and/or facial swelling.
  • Galliprant® is not approved for use in dogs over under month of age under 8 pounds in weight, or dogs used for breeding, pregnant or nursing.
  • Since Galliprant® has not been tested in cats, it should not be used in this species.
  • Galliprant® may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Galliprant®.  Do not give Galliprant® with drugs such as aspirin, corticosteroids such as prednisone, and other NSAID drugs such as meloxicam or carprofen.

How Galliprant® is Supplied

  •   Galliprant® is available as 20 mg, 60 mg, and 100 mg tablets.
  •   Bottle sizes include 7, 30 and 90 count.

Dosing Information of Galliprant® for Dogs

  • Medication should never be administered without first consulting your veterinarian.
  • The typical dose administered to dogs for control of pain associated with arthritis is 0.5 to 1 mg per pound (1 to 2 mg/kg) every 24 hours orally as needed.
  • Galliprant® may be administered with or without food.
  • Half tablet increments may be prescribed.
  • It is recommended to use the lowest dose to provide pain control.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse.

We hope this gives you more information about the drug Galliprant®. For additional information or to report an adverse drug reaction, please contact the FDA at 1-888-FDA-VETS.

Resources & References:

  •      ASPCA Pet Poison Hotline.
  •      Current Veterinary Therapy XV, Bonagura and Twedt.
  •      Pet Poison Helpline.
  •      Plumb’s Veterinary Handbook by Donald C. Plumb, 9th Edition.
  •      Textbook of Veterinary Internal Medicine, Ettinger & Felman.