Chronic Renal (Kidney) Failure (CRF) in Dogs

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Causes of Chronic Renal Failure in Dogs

  • Chronic interstitial nephritis (inflammation of the kidney) of unknown cause (most common)
  • Amyloidosis (when the protein amyloid is deposited in various tissues tissues become waxy and nonfunctioning)
  • Chronic glomerulonephritis (a variety of nephritis)
  • Chronic obstructive uropathy (any disease in the urinary tract)
  • Chronic pyelonephritis (inflammation of the kidney and renal pelvis)
  • Familial renal disease (disease pets can be born with such as in cocker spaniel, Lhasa apso, shih tzu, Norwegian elkhound, Samoyed, Doberman pinscher, soft-coated wheaten terrier, bull terrier, golden retriever, and others)
  • From acute renal failure
  • Hypercalcemic nephropathy (caused by high blood calcium)
  • Leptospirosis (an infectious disease of all species)
  • Cancer of the kidney
  • Veterinary care should include diagnostic tests and subsequent treatment recommendations.

    In-depth Information on Diagnosis 

    Diagnostic tests must be performed to confirm the diagnosis of CRF and exclude other diseases that may cause similar symptoms.

    Tests may include:

  • Your veterinarian should perform a complete medical history and a thorough physical examination.
  • Complete blood count (Hemogram; CBC) may be performed to evaluate for signs of infection, inflammation, anemia or platelet abnormalities. Performing a buccal mucosal bleeding time may best assesses abnormal platelet function.
  • Biochemical profile tests, such as, serum creatinine and BUN concentrations are typically elevated with CRF. Serum phosphorus and potassium concentrations may also be increased.
  • Urinalysis tests may show a low specific gravity, which is common with CRF. Abnormal urine protein or sediment may indicate infection or glomerular disease.
  • Abdominal radiographs (X-rays) may show small kidney size, which is common with CRF, but normal renal size does not rule out CRF.

    Other diagnostic tests may be recommended on a case-by-case basis.

    Tests may include:

  • Kidney ultrasonography can provide additional information about the kidneys. Kidneys with chronic disease are typically small and sometimes irregularly shaped. Large kidneys may indicate polycystic renal disease, cancer or an acute kidney disease). Some pets can have a normal ultrasound with CRF.
  • Excretory urography may be useful in the evaluation of abnormalities in renal size, shape or location. It may also be valuable in the detection of obstruction, cancer or stones.
  • Urine culture should be performed to evaluate for the presence of upper or lower urinary tract infection.
  • Blood gas analysis will allow evaluation of acid base disturbances.
  • Leptospira antibody serologic tests may be needed to diagnosis this infection.
  • Arterial blood pressure may be needed to determine the presence of complicating hypertension (high blood pressure).
  • Endogenous or exogenous creatinine clearance can be used to measure glomerular filtration rate in pets with normal blood work and who are suspected to have renal disease.
  • Urine protein/creatinine ratio is useful to evaluate urinary protein loss in pets suspected to have glomerular disease.
  • Fractional excretion of electrolytes (sodium, potassium, chloride, and phosphorus) may be useful in evaluation of animals with suspected renal tubular disorders.
  • Radioisotope clearances may be used to determine kidney filtration and blood flow. 
  • In-depth Information on Treatment 

    Treatment of chronic renal failure in dogs must be individualized based on the severity of the condition, the cause, secondary diseases or conditions and other factors that must be analyzed by your veterinarian. A search for reversible causes of kidney failure should be completed. The ultimate goal of the management of CRF is to provide supportive care while trying to treat and eliminate secondary factors aggravating kidney failure such as, infections, dehydration, malnutrition, anemia, etc.

    Treatments for CRF may include:

  • Fluid therapy is important to correct dehydration and abnormalities in serum electrolytes. Care must be taken to avoid over-hydrating the patient, because the kidneys may not be able to produce urine to get rid of the excess fluid.
  • Dietary therapy may include a diet that is low in protein and phosphorus. Special diets are formulated for pets with chronic renal failure such as Prescription diet u/d, CNM NF-FORMULA, Eukanuba Nutritional Kidney Formula/Early Stage/Canine, Eukanuba Nutritional Kidney Formula/Advanced Stage/Canine, IVD Modified.
  • Management of abnormal blood potassium may be done. The level may be low or high (with late stage of kidney failure). Correction of metabolic acidosis may be performed by treating the problem with sodium bicarbonate if needed.
  • Elevated phosphorus may be treated with intestinal phosphorus binders such as aluminum hydroxide and aluminum carbonate.
  • Control of vomiting may be treated with drugs that may beneficial, including: cimetidine (Tagamet®), ranitidine (Zantac®) or famotidine (Pepcid®).
  • Anabolic steroids are available, but there are no long-term studies demonstrating their efficacy.
  • Anemia may be treated with recombinant human erythropoietin. Dogs treated with Epogen have demonstrated resolution of anemia, weight gain, improved appetite, improved haircoat and improved sociability with their owners. There are some risks associated with its use.
  • Vitamin D (calcitriol or 1,25-dihydroxycholecalciferol) may be supplemented (as Calcitriol synthesis is impaired with CRF). The benefits of supplementation are controversial. Calcitriol must only be used after hyperphosphatemia has been adequately controlled.
  • Patient monitoring is an important part of continuing optimal treatment. Monitoring may include the following: serial body weight (to determinations facilitate proper fluid therapy); measurement of urine output; packed cell volume (PCV) and total plasma proteins (will help monitor fluid load); and serial determinations of serum biochemistry are necessary to determine if the animal is responding to treatment. These determinants will help determine the proper fluid and drug therapy.
  • Treatment may be required from three to five days, depending on the response and secondary causes. If treatment fails, dialysis or kidney transplant may be a treatment possibility. Referral may be required for dialysis treatment. CRF may be progressive despite treatment. The prognosis for recovery of renal function depends on the severity of the renal lesions and the cause of CRF. Euthanasia may be considered for pets that do not respond to treatment.
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