Lufenuron and Milbemycin (Sentinel Flavor Tabs®) For Dogs


Overview of Lufenuron and Milbemycin For Dogs

  • Lufenuron and Milbemycin, Sentinel Flavor Tabs®, are used to control heartworms, fleas, and several common internal parasites in dogs.
  • Parasitic infections are common in dogs and include both external parasites (fleas, ticks, mites), and internal parasites (intestinal worms, lungworms and heartworms).
  • Control of insect parasites, such as fleas, can be achieved by a number of approaches. One of the most novel methods is the use of insect growth regulators. These drugs arrest the development of insect parasites yet demonstrate great safety when administered to animals.
  • Lufenuron belongs to a class of drugs known as insect development inhibitors/insect growth regulators.
  • Lufenuron inhibits insect development within the insect egg. This prevents the egg from maturing to an adult insect.
  • Lufenuron is most commonly administered for flea control in dogs and in cats. It does not control ticks.
  • Dogs and cats already affected with fleas, or those with flea-allergy dermatitis, first should be treated with an insecticide approved for that species.
  • Lufenuron is available by veterinary prescription as a single drug (Program®) for dogs and for cats. It has also been combined with the drug milbemycin oxime into a single pill (Sentinel Flavor Tabs®) to provide broad spectrum control of parasites.
  • Milbemycin oxime is a parasite control drug effective in controlling or preventing several of the most common parasitic diseases of dogs.
  • Milbemycin oxime is approved by the Food and Drug Administration to control hookworm, roundworm and certain whipworm infections and to prevent heartworm infection in dogs.
  • The combination of lufenuron and milbemycin oxime (Sentinel Flavor Tabs®) is only approved for use in dogs.
  • Additional information about the individual drugs is available under lufenuron or milbemycin oxime.
  • Lufenuron and milbemycin oxime is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.

Brand Names and Other Names of Lufenuron and Milbemycin

  • This drug is registered for use in animals only.
  • Human formulations: None
  • Veterinary formulations: Sentinel Flavor Tabs® (Novartis Animal Health)

Uses of Lufenuron and Milbemycin for Dogs

  • Lufenuron and milbemycin are used to control heartworms, fleas and several common internal parasites including roundworms, hookworms and some whipworms.

Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, lufenuron and milbemycin oxime can cause side effects in some animals.
  • Lufenuron and milbemycin oxime should not be used in animals with known hypersensitivity or allergy to the drug.
  • Any animals given the lufenuron and milbemycin combination should be tested for heartworms prior to administration. Administration to heartworm positive dogs can lead to a potentially severe shock-like reaction.
  • Some reported adverse effects include vomiting, diarrhea, lack of appetite or itchy skin. These are relatively uncommon.

How Lufenuron and Milbemycin Combination Is Supplied

  • The combination of lufenuron and milbemycin is available in various size tablets appropriate for the size of the dog.

Dosing Information of Lufenuron and Milbemycin for Dogs

  • Medication should never be administered without first consulting your veterinarian.
  • Lufenuron and milbemycin combination is dosed based on the dog’s weight range.
  • Lufenuron is dosed at 5 mg per pound (10 mg/kg) once a month.
  • Milbemycin is dosed at 0.25 to 0.5 mg per pound (0.5 to 1 mg/kg) once a month.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian.
  • This information is provided by veterinarians. For official prescribing information for this drug, read the article “Sentinel®.”


<!–Anti-Parasitic Drugs (External)
Anti-Parasitic Drugs (Heartworms)
Anti-Parasitic Drugs (Gastrointestinal & Internal)



<!–Dermatology & Integumentary diseases
Gastroenterology & Digestive diseases
Cardiology & Cardiovascular diseases



number-of-posts0 paws up