Metaflumizone (ProMeris® and ProMeris Duo™) for Dogs and Cats

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NOTE: Pfizer Animal Health, the maker of ProMeris flea and tick control products, discontinued production of ProMeris in 2011. The Journal of Veterinary Dermatology published an article at North Carolina State University researchers who found that ProMeris has the potential to trigger a variant of pemphigus foliaceus in dogs. The information about ProMeris is below but the drug is no longer available. 

Overview of Metaflumizone for Canines and Felines

  • Metaflumizone, better known asProMeris™, is a drug that was on the market that provided broad spectrum flea and tick control to dogs and flea control to cats. It contains antiparasitic agents used to kill adult fleas and ticks.
  • ProMeris™ for Dogs is a product labeled for dogs only (Promeris Duo™) that contains two active ingredients that include metaflumizone and amitraz. The product labeled for cats (Promeris®) contains metaflumizone.
  • Metaflumizone works by interfering with the nerve function of fleas, ultimately resulting in death.
  • Amitraz kills ticks by disrupting their nervous system function that results in their inability to feed causing them to detach from the dog, become paralyzed and die.
  • ProMeris™ is a topical solution that is water proof.
  • The effects last about 30 days against ticks and 30 to 45 days against fleas.
  • Promeris is a Prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian, available in March of 2008.
  • Brand Names and Other Names of Metaflumizone

  • This drug is Registered for use in animals only.
  • Human formulations: None
  • Veterinary formulations: ProMeris® (Fort Dodge), Promeris Duo™ (Fort Dodge)
  • Uses of Metaflumizone for Dogs and Cats

  • ProMeris is used in the control and treatment of adult flea and tick infestations in dogs and flea infestations in cats. For more information on flea infestations, please see Flea Infestation in Cats and/or Flea Infestation in Dogs. For more information on tick infestations, please read Tick Infestations in Dogs.
  • ProMeris may benefit pets with Flea Allergy Dermatitis
  • Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, ProMeris Duo™ and ProMeris®can cause side effects in some animals.
  • ProMeris Duo ™ and ProMeris® should not be used in animals with known hypersensitivity or allergy to the drug.
  • ProMeris Duo ™ and ProMeris® is not recommended for use in kittens and puppies less than 8 weeks of age.
  • ProMeris Duo™ and ProMeris® may interact with other medications. Consult with your veterinarian to
  • ProMeris Duo ™ and ProMeris® is a topical agent and temporary irritation at the site of application is possible. Promeris has been associated with triggering a variant of pemphigus foliaceus in dogs. 
  • Spotted areas may appear wet or oily for up to 24 hours.
  • Overdose is rare and no adverse effects have been reported even up to 5 times the dose.
  • How ProMeris is Supplied

  • ProMeris is available as a topical solution available in five sizes depending on the weight of the pet. Each card contains 3 or 6 pipettes.

    ProMeris Duo ™ for dogs, the sizes are:

    Extra small (XS) = < 11 pounds)

    Small = > 11 – 22 pounds

    Medium = > 22 – 55 pounds

    Large = > 55 to 88 pounds

    Extra large (XL) = > 88 to 110 pounds

    ProMeris® for cats, the sizes are:

    Small* = under 9 pounds

    Large = 90 pounds and over

    *Kittens 8 weeks to 6 months should be treated with the Small size.

  • Dosing Information of Metaflumizone for Dogs and Cats

  • Medication should never be administered without first consulting your veterinarian.
  • The dose of Promeris for preventative flea control is administration of the product every 4 to 6 weeks throughout the flea season. The dose for flea prevention in dogs is administration every 4 weeks throughout the tick season.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. The manufacturer suggests monthly treatments to protect against flea re-infestation although the product may be effective for up to six weeks. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance. 
  • IMPORTANT NOTE: Pfizer Animal Health, the maker of ProMeris flea and tick control products, discontinued production of ProMeris and thus is no longer available.


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