Yohimbine (Yobine®, Antagonil®) for Dogs and Cats

Yohimbine (Yobine®, Antagonil®) for Dogs and Cats


Overview of Yohimbine for Dogs and Cats

  •  Yohimbine ,known also as Yobine® and Antagonil®, is often used for dogs and cats for the reversal of alpha-2 agonists, like xylazine and detomidine, and for amitraz toxicity.
  • In veterinary medicine, it is sometimes necessary to administer a drug to reverse the effects of another drug. Yohimbine is such a drug. It may be used safely to reverse the effects drugs, such as xylazine and detomidine.
  • Yohimbine is a centrally-acting alpha-2 receptor antagonist.
  • Yohimbine is the principal indole alkaloid derived from the bark of the Yohimbe tree. It is also found in the Rauwolfia root and is structurally and functionally similar to reserpine.
  • Yohimbine is administered almost exclusively by injection in domestic animals. The oral route of administration is employed in humans when yohimbine is indicated for the treatment of impotence.
  • In the United States, yohimbine is a prescription drug and can only be administered by a veterinarian.
  • Brand Names and Other Names of Yohimbine

  • Veterinary formulations: Yobine® (Lloyd) and Antagonil® (Wildlife Labs)
  • Human formulations: Aphrodyne® (Star), Dayto Himbine® (Dayton), Yocon® (Palisades) and Yohimex® (Kramer)
  • Uses of Yohimbine for Dogs and Cats

  • Yohimbine is used for reversal of alpha-2 agonists, like xylazine and detomidine.
  • It may also be helpful in reversing amitraz toxicity.
  • Yohimbine is partially effective in reversing the CNS depressant effects of a number of centrally-acting drugs (e.g. pentobarbital, ketamine, benzodiazepines).
  • Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, yohimbine may cause unacceptable side effects in some animals.
  • Yohimbine should not be used in animals with known hypersensitivity or allergy to the drug.
  • Yohimbine should be used with caution in animals with known kidney disease or seizure disorders.
  • Yohimbine may interact with other medications. Consult your veterinarian to determine if other drugs your pet is receiving could interact with yohimbine. Such drugs include phenylephrine, phenylpropanolamine, and tricyclic antidepressants.
  • How Yohimbine is Supplied

  • Yohimbine is available in an injectable form in a 2 mg/mL or 5 mg/mL concentration. It is also available in 5.4 mg tablets for human use.

    Dosing Information of Yohimbine for Dogs and Cats

    Yohimbine is usually administered in a hospital setting.

  • For reversal of xylazine, yohimbine is dosed at 0.05 – 0.1 mg per pound (0.1 to 0.2 mg/kg) slowly by intravenous route.
  • For amitraz toxicity, yohimbine is dosed at 0.05 mg per pound (0.1 mg/kg) intravenous.
  • For anti-emesis, yohimbine is dosed at 0.12 to 0.25 mg per pound (0.25 to 0.5 mg/kg) subcutaneous or intramuscular, up to every 12 hours.
  • The duration of administration depends on the condition being treated, response to the medication, and the development of any adverse effects.
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