References for Pet Drug Library on Zeel
- Effectiveness of the homeopathic preparation Zeel compared with carprofen in dogs with osteoarthritis.J Am Anim Hosp Assoc. 2011 Jan-Feb;47(1):12-20.
Stephan Neumann1; Pelle Stolt; Gabriele Braun; Klaus Hellmann; Erich Reinhart
1Clinic for Small Animals, Institute of Veterinary Medicine, University of Goettingen, Germany. email@example.com
The authors compared the symptomatic effectiveness of a complex homeopathic preparation Zeel (1-3 tablets orally per day depending on body weight) to carprofen (4 mg/kg body weight) in dogs (n=68) aged >1 yr diagnosed with osteoarthritis in a multicenter, prospective, observational open-label cohort study in 12 German veterinary clinics. The active treatment period was 56 days. Symptomatic effectiveness, lameness, stiffness of movements, and pain on palpation were evaluated by treating veterinarians and owners. Clinical signs of osteoarthritis improved significantly (P<0.05) at all time points (days 1, 28, and 56) with both therapies. At the end of the treatment period, effectiveness was comparable in both groups. Both treatment regimens were well tolerated with only three treatment-related adverse events, all in the carprofen group.
Evaluating complementary therapies for canine osteoarthritis–Part II: a homeopathic combination preparation (Zeel).
Evid Based Complement Alternat Med. December 2009;6(4):465-71.
Anna Hielm-Björkman1; Riitta-Mari Tulamo; Hanna Salonen; Marja Raekallio
1Faculty of Veterinary Medicine, Department of Equine and Small Animal Medicine, University of Helsinki, Finland. firstname.lastname@example.org
A homeopathic combination preparation (HCP) for canine osteoarthritic pain was evaluated in a randomized, double-controlled and double-blinded clinical trial. Forty-four dogs with osteoarthritis (OA) that were randomly allocated into one of three groups completed the study. All dogs were fed test products or placebo for 8 weeks. The dogs were evaluated at the clinic four times, with 4-week intervals. Six different variables were assessed: veterinary-assessed mobility, two force plate variables, an owner-evaluated chronic pain index and pain and locomotion visual analogue scales (VASs). Intake of extra non-steroidal anti-inflammatory drugs was also evaluated. A Chi-squared test and a Mann-Whitney test were used to determine significant improvement between groups. When changed into dichotomous responses of 'improved' or 'not improved' three out of the six variables showed a significant difference (P = 0.016, P = 0.008, P = 0.039) in improved dogs per group, between the HCP group and the placebo group. The odds ratios were over one for the same variables. As extent of improvement in the variables from start to end of treatment, the HCP product was significantly more improved in four (P = 0.015, P = 0.028, P = 0.049, P = 0.020) of the six variables, compared with the placebo. Our results indicated that the HCP Zeel(R) was beneficial in alleviating chronic orthopedic pain in dogs although it was not as effective as carprofen.
I hope this gives you more information about using Zeel in dogs and cats.