Pantoprazole (Protonix®, Pantoloc®) for Dogs and Cats

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Overview of Using Pantoprazole in Dogs and Cats

  • Pantoprazole, also known by the brand names Protonix® and Pantoloc®, is used to prevent and treat stomach ulcers and gastric acid related diseases in dogs and cats. It has been used with human medicine for years and is growing in popularity for use in dogs and cats.
  • Normally, the stomach produces gastric acid to assist in digestion. Under certain conditions, however, this acid can injure the lining (mucosa) of the stomach. The result can be stomach ulcers or erosions (“scratches”) in the stomach lining. Ulcers are also a common consequence of treatment with some drugs, especially NSAID drugs, such as aspirin.
  • When there is a risk of ulcer formation, there are many ways to heal the stomach or protect the lining. These anti-ulcer treatments can be classified as antacids (Maalox®), H2 blockers (Pepcid AC®), proton pump blockers (Prilosec®) and prostaglandin analogs, such as the drug Misoprostol and Pantoprazole.
  • Pantoprazole inhibits stomach acid secretions and has a protective effect on blood flow and the lining of the stomach wall.
  • Pantoprazole is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
  • This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug.

Brand Names and Other Names of ​Pantoprazole

  • This drug is registered for use in animals only.
  • Human formulations: Pantoprazole (Protonix®, Pantoloc®)
  • Veterinary formulations: None

Uses of Pantoprazole (Protonix®, Pantoloc®) for Dogs

Precautions and Side Effects

  • While generally safe and effective when prescribed by a veterinarian, Pantoprazole can cause side effects in some animals.
  • Pantoprazole should not be used in animals with known hypersensitivity or allergy to the drug.
  • Pantoprazole may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Pantoprazole. Such drugs include certain anti-fungal drugs such as ketoconazole and itraconazole, iron, thyroid supplements, sucralfate, and/or warfarin.
  • The most commonly reported adverse effect is diarrhea.

How Pantoprazole Is Supplied

  • Pantoprazole is available in delayed-release tablets in 20 mg and 40 mg sizes.
  • It is available as an oral suspension at 40 mg.
  • It is available as in injection in 40 mg vials (Protonix I.V. ®). When reconstituted, the product is mixed as labeled is stable for up to two hours at room temperature. If diluted it can be stable for up to 22 hours at room temperature.

Dosing Information of Pantoprazole (Protonix) for Dogs

  • Medication should never be administered without first consulting your veterinarian.
  • It is recommended to give with food first thing in the morning.
  • Do not break or cut tablets.
  • Pantoprazole is commonly dosed at 0.3 to 0.45 mg per pound (0.7 to 1 mg/kg) once daily. It can be given intravenously (IV) or orally. Do not give intramuscularly (IM) or subcutaneously (SQ). When given IV should be given slowly over 15 minutes.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your dog or cat feels better, the entire treatment plan should be completed to prevent relapse.

References and Resources

  • Bersenas A. Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. AJVR, 2005.
  • ASPCA Pet Poison Hotline
  • Current Veterinary Therapy XV, Bonagura, and Twedt
  • Pet Poison Helpline
  • Plumb’s Veterinary Handbook by Donald C. Plumb, 9th Edition
  • Textbook of Veterinary Internal Medicine, Ettinger & Felman

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